Biophysicist from the University of Johann Wolfgang Von Goethe University (Frankfurt, Germany) and PhD from the University of Bremen. His thesis (summa cum laude) won the Bremer Studienpreis. He completed postdocs at the CIQUIBIC Biological Chemistry Research Center (Córdoba, Argentina) and the CECS Scientific Studies Center (Valdivia, Chile).
Since 2006 he created and leads the Scientific Image Processing Laboratory (Scian-LAB) at the Faculty of Medicine of the University of Chile. He is founder of CEDAI SpA.
He is currently Principal Investigator of the Institute of Biomedical Neuroscience BNI, Director of the Center for Medical Informatics and Telemedicine CIMT and the National Center for Health Information Systems, CENS.

Medical and Biomedical Informatics
Image Processing
Optical Microscopy

Biochemist from Pontificia Universidad Católica de Chile and PhD in Sciences from Universidad de Chile. She did her post-doctorate with a Pew Fellowship in the laboratory of Dr. Charles Zuker at the University of California, San Diego.
He returned to Chile in 1998 as Academician of the Institute of Biomedical Sciences of the Faculty of Medicine of the University of Chile.
She is currently Professor of the Department of Neuroscience of the Faculty of Medicine and alternate director of the BNI, she leads the laboratory of cellular and molecular neurobiology at the University of Chile, where she is dedicated to the study of various aspects of the nervous system using the vinegar fly Drosophila melanogaster as a model.
She is currently Principal Investigator of the Institute of Biomedical Neuroscience BNI, Director of the Center for Medical Informatics and Telemedicine CIMT and the National Center for Health Information Systems, CENS.

Role of MAGUK proteins in the structure and function of glutamatergic synapses
The role of MAGUK family proteins in the localization and trafficking of essential components of glutamatergic synapses was studied. Specifically, the regulation of presynaptic calcium by plasma membrane Ca-ATPase and voltage-dependent calcium channels is being studied, both of which are dependent on the presence of MAGUK proteins.

Lactate transporters in the brain, their role in synaptic function and cognitive processes
The role of alternative sources of glucose, specifically glucose in neuronal energy management, was studied.

Full Professor at the University of Chile, Adjunct Professor at the Buck Institute, California. Scientific Director of the Neurounion Foundation and associate researcher of the Fondap of Geroscience. He has received multiple national and international awards for his scientific work.
He directs the Proteostasis Control and Biomedicine Laboratory, where he investigates the mechanisms involved in the maintenance of cellular proteostasis and its implications in the development of neurodegenerative diseases, such as Parkinson's, Alzheimer's, Huntington's disease and Amyotrophic Lateral Sclerosis (ALS).
This laboratory represents one of the most productive groups in the area of biomedicine in Chile and Latin America. Its work is supported by multiple international foundations.

Mechanisms of proteostasis control
To study cellular strategies that understand how the cell adapts to alterations that perturb protein homeostasis or proteostasis. In particular, study the role of the response to more folded proteins or UPR on conditions that generate stress at the endoplasmic reticulum level.
Decrease neurodegeneration
Therapeutic strategies to reduce neuronal damage and neuronal dysfunction based on pharmacological and gene therapy through a close partnership with Genzyme Corporation in the United States.

Physician and PhD in Biomedical Sciences from the University of Chile. He did his postdoctorate at University College London (UCL, UK), where he later remained as an honorary researcher.
He is currently a senior researcher at the Institute of Biomedical Neuroscience, BNI, full professor at the Faculty of Medicine of the University of Chile, and director of the Laboratory of Ontogenetic Studies (LEO).
He has received awards from the Howard Hughes Medical Institute (USA), Welcome Trust (UK), Third World Academy of Sciences (Italy), Fundación Andes (Chile), and the Faculty of Medicine of the University of Chile.

Origin and evolution of brain asymmetries
We investigate the morphological, connectivity and molecular patterns that underlie asymmetries in the nervous system. We study the genes and morphogenetic events that are responsible for breaking the symmetry of the developing brain, and the mechanisms of ontogeny that are modulated in evolution to give rise to morphological variability between species.
Origin and transformation of shape in developing tissues
We study the role of mechanical forces and biochemical signals in the expansion, contraction and deformation of developing tissues. We investigate how local cellular changes give rise to global tissue events that generate new patterns and shapes within a developing tissue.

Degree in Biological Sciences and Master in Physiological Sciences from the University of Chile, PhD in Sciences from the University of Pennsylvania. He did his postdoctorate at the Neuroscience Center of the University of California, Davis.
He is a Founding Member of the Chilean Society of Neuroscience and full professor of the Faculty of Medicine of the University of Chile.
Dr Maldonado is principal investigator of the BNI.

Neurophysiological correlates of active perception
Perception largely arises from sensory changes self-triggered by the organism itself. We study the neurophysiological mechanisms of how motor acts modulate perceptual activity. For this we record brain activity in rats or humans while they perform free exploration or discriminate visual stimuli, triggered by a motor act.
Neurophysiological correlates of psychiatric and neurological disorders
We are looking for measures or biomarkers that could improve the diagnosis and evaluate the course of treatment of psychiatric and neurological diseases, as well as contribute to the understanding of pathogenesis. This approach will allow early detection of diseases and may help in more effective therapy. In this area we studied a group of patients diagnosed with schizophrenia, and Alzheimer's disease. In patients and healthy volunteers, we studied eye movements and brain activity measured with EEG to find behavioral and electroencephalographic markers of these pathologies.